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Odorant molecules and human olfactory receptor

Abstract : When a molécule interacts with the olfactory sensorial system, it carries out the encoding of the characteristics. The treatment and processing of this data gives rise to a cérébral construction:The "odor". THE PERCEPTION on thousands of odorant molecules by a few hundred human olfactory receptors (ORs) results in a combined coding.one OR can recognize several odorant molécules and one odorant molecule can be deterred by different ORs. Moreover, the odorants can be agonist (activators) or antagonist (mhibitors) as a function of the ORs This makes the coding of the odors even more complex and can be the cause of interactions between odors (examples: masking, synergy, Ishii et al. 2008) observed when the odorants are in a mix, which constitutes the most frequent case in "daily life" ln this way, it is often difficult to predict the perceived odor of an odorant molecule from its structure alone. However, the detection of the odorants by the ORs constitutes the starting point of the cerebral construction that results in the conscious perception of what wc call "odor". Because of this, it is possible to make the hypothesis of a link between the structure of the odorant molecules, their level of interaction with the ORs and the quality of the odor that they generate. The purpose of our study was to test this hypothesis
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  • HAL Id : hal-02655865, version 1
  • PRODINRA : 29630

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Guenhaël Sanz, Thierry Thomas-Danguin, El Hassan Hamdani, Claire Le Poupon, Loïc Briand, et al.. Odorant molecules and human olfactory receptor. Parfums Cosmétiques Actualités, 2009, 205 (1), pp.1-5. ⟨hal-02655865⟩

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