Skip to Main content Skip to Navigation
Journal articles

Differential expression of adhesion molecules and chemokines between nasal and small intestinal mucosae: implications for T- and sIgA(+) B-lymphocyte recruitment

Abstract : Nasal and small intestinal mucosae are the first sites of contact with infectious agents and the sites of T-cell-mediated and secreted immunoglobulin A (IgA)-mediated defences against pathogens. We investigated the factors controlling the infiltration of CD3(+) T lymphocytes and surface IgA(+) (sIgA(+)) B lymphocytes into swine epithelium and lamina propria (LP) within and between these two mucosal effector sites. Vascular addressins, vascular cell adhesion molecule 1 and mucosal addressin cell adhesion molecule-1 were reciprocally expressed in both mucosae. Strong expression of alpha(4)beta(1) relative to alpha(4)beta(7) was characteristic of CD3(+) T cells in nasal mucosa LP and epithelium and of sIgA(+) cells in nasal mucosa epithelium. The same profile was observed on corresponding blood cells. Conversely, higher levels of integrins beta(7) and alpha(4)beta(7) than alpha(4)beta(1) were characteristic of CD3(+) T cells and sIgA(+) cells in the small intestine. However, about 40% of the LP-activated sIgA(+) cells displayed sIgA(high), integrin alpha(4)beta(high)(1) expression. Whereas CCL19, CXCL12, CCL21 and CCL28 messenger RNAs were similarly expressed in both mucosae, CCL25 messenger RNA was only expressed in the small intestine. Thus, the nasal and small intestine mucosae represent separate compartments for infiltration by CD3(+) T cells and sIgA(+) effector cells, with the exception of a population of small intestine activated sIgA(+) cells, which may gain access to both mucosae.
Document type :
Journal articles
Complete list of metadata

https://hal.inrae.fr/hal-02658798
Contributor : Migration Prodinra Connect in order to contact the contributor
Submitted on : Saturday, May 30, 2020 - 12:53:55 PM
Last modification on : Thursday, May 6, 2021 - 2:22:37 PM

Links full text

Identifiers

Collections

Citation

Dorothée Bourges, Claire Chevaleyre, Caihong Wang, Mustapha Berri, Xiaomei Zhang, et al.. Differential expression of adhesion molecules and chemokines between nasal and small intestinal mucosae: implications for T- and sIgA(+) B-lymphocyte recruitment. Immunology, Wiley, 2007, 122 (4), pp.551-561. ⟨10.1111/j.1365-2567.2007.02671.x⟩. ⟨hal-02658798⟩

Share

Metrics

Record views

13