Dairy and industrial sources of trans fat do not impair peripheral insulin sensitivity in overweight women - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Access content directly
Journal Articles The American Journal of Clinical Nutrition Year : 2009

Dairy and industrial sources of trans fat do not impair peripheral insulin sensitivity in overweight women

Abstract

Background: The 2 major dietary sources of trans fatty acids (TFAs) are partially hydrogenated oils and ruminant-derived products. Epidemiologic data suggest that chronic consumption of industrial sources of TFAs could be damaging to insulin sensitivity, but intervention studies on this issue have remained inconclusive. Objective: The trial was designed to compare the effects of dairy compared with industrial sources of TFAs on insulin sensitivity in overweight women. Design: Sixty-three healthy women with abdominal obesity [waist circumference > 88 cm and a body mass index (in kg/m(2)) > 28] were recruited. After a run-in period, the volunteers were randomly assigned to consume 1 of 3 four-week diets: 60 g low-TFA lipids/d (0.54 g/d; n = 21), ruminant TFA-rich lipids (4.86 g/d; n = 21), or industrial TFA-rich lipids (5.58 g/d; n = 21). Changes in peripheral insulin sensitivity were assessed by using hyperinsulinemiceuglycemic clamps. Results: After the intervention period, fasting glycemia and insulinemia and insulin sensitivity were not significantly modified in either group (P > 0.05). Conclusions: These data indicate that consumption of dairy- and industrial-source TFAs for 4 wk at nutritional levels do not impair peripheral insulin sensitivity in insulin-resistant women. Our study may not preassess the effects of TFAs in normal insulin-sensitive individuals. This trial was registered at clinicaltrials.gov as NCT00617435. Am J Clin Nutr 2009;90:88-94.

Dates and versions

hal-02661198 , version 1 (30-05-2020)

Identifiers

Cite

Anne-Laure Tardy, S. Lambert-Porcheron, C. Malpuech-Brugère, Christophe Giraudet, Jean-Paul Rigaudière, et al.. Dairy and industrial sources of trans fat do not impair peripheral insulin sensitivity in overweight women. The American Journal of Clinical Nutrition, 2009, 90, pp.88-94. ⟨10.3945/ajcn.2009.27515⟩. ⟨hal-02661198⟩
12 View
0 Download

Altmetric

Share

Gmail Facebook X LinkedIn More