In vivo activities of recombinant divercin V41 and its structural variants against <em>Listeria monocytogenes</em>

Recombinant divercin RV41 (DvnRV41) and its structural variants were used in this study to assess their antilisterial activities in vivo in mice challenged intravenously with Listeria monocytogenes EGDe. Treatment with DvnRV41 before and after infection permitted a conclusion as to the capacities of this peptide to retain activity and reduce growth of L. monocytogenes EGDe. Moreover, the use of structural variants for the first time in vivo and the reductions of their activities confirmed the importance of certain amino acids in antilisterial activity.

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Sciences du Vivant [q-bio]

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rihakova_2010_1.pdf (45.36 Ko)

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Soumis le : dimanche 31 mai 2020-00:04:57

Dernière modification le : vendredi 15 mars 2024-12:12:03

Dates et versions

hal-02662367 , version 1 (31-05-2020)

Identifiants

HAL Id : hal-02662367 , version 1
DOI : 10.1128/AAC.00765-09
PRODINRA : 282225
PUBMED : 19841145
WOS : 000272931200082

Citer

Jitka Rihakova, Jean-Michel Cappelier, Isabelle Hue, Katerina Demnerova, Michel M. Federighi, et al.. In vivo activities of recombinant divercin V41 and its structural variants against Listeria monocytogenes. Antimicrobial Agents and Chemotherapy, 2010, 54 (1), pp.563-564. ⟨10.1128/AAC.00765-09⟩. ⟨hal-02662367⟩

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In vivo activities of recombinant divercin V41 and its structural variants against Listeria monocytogenes

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