Role of sulfur amino acids in controlling nutrient metabolism and cell functions: implications for nutrition - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Access content directly
Journal Articles (Review Article) British Journal of Nutrition Year : 2009

Role of sulfur amino acids in controlling nutrient metabolism and cell functions: implications for nutrition

Sophie Tesseraud
Anne Collin
Iban Seiliez

Abstract

Protein synthesis is affected when an insufficient level of sulfur amino acids is available. This defect may originate from dietary amino acid deficiency and/or excessive amino acid utilisation for other purposes such as the synthesis of glutathione and acute-phase proteins during catabolic stress. Sulfur amino acids are recognised to exert other significant functions since they are precursors of essential molecules, are involved in the methylation process, participate in the control of oxidative status, and may act as mediators affecting metabolism and cell functions. Despite this increased understanding of the role of sulfur amino acids, many questions still remain unanswered due to the complexity of the mechanisms involved. Moreover, surprising effects of dietary sulfur amino acids have been reported, with the development of disorders in cases of both deficiency and excess. These findings indicate the importance of defining adequate levels of intake and providing a rationale for nutritional advice. The aim of the present review is to provide an overview on the roles of sulfur amino acids as regulators of nutrient metabolism and cell functions, with emphasis placed on the implications for nutrition.

Dates and versions

hal-02664413 , version 1 (31-05-2020)

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Sophie Tesseraud, Sonia Metayer-Coustard, Anne Collin, Iban Seiliez. Role of sulfur amino acids in controlling nutrient metabolism and cell functions: implications for nutrition. British Journal of Nutrition, 2009, 101 (8), pp.1132-1139. ⟨10.1017/S0007114508159025⟩. ⟨hal-02664413⟩
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