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Analysis of the peripheral T-cell repertoire in kidney transplant patients

Abstract : The long-term stability of renal grafts depends on the absence of chronic rejection. As T cells play a key role in rejection processes, analyzing the T-cell repertoire may be useful for understanding graft function outcomes. We have therefore investigated the power of a new statistical tool, used to analyze the peripheral blood TCR repertoire, for determining immunological differences in a group of 229 stable renal transplant patients undergoing immunosuppression. Despite selecting the patients according to stringent criteria, the patients displayed heterogeneous T-cell repertoire usage, ranging from unbiased to highly selected TCR repertoires; a skewed TCR repertoire correlating with an increase in the CD8(+)/CD4(+) T-cell ratio. T-cell repertoire patterns were compared in patients with clinically opposing outcomes i.e. stable drug-free operationally tolerant recipients and patients with the "suspicious" form of humoral chronic rejection and were found significantly different, from polyclonal to highly selected TCR repertoires, respectively. Moreover, a selected TCR repertoire was found to positively correlate with the Banff score grade. Collectively, these data suggest that TCR repertoire categorization might be included in the calculation of a composite score for the follow-up of patients after kidney transplantation.
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https://hal.inrae.fr/hal-02664822
Déposant : Migration Prodinra <>
Soumis le : dimanche 31 mai 2020 - 05:32:32
Dernière modification le : vendredi 12 juin 2020 - 10:43:26

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P. Miqueu, Nicolas Degauque, Marina Guillet, Magali Giral, Catherine Ruiz, et al.. Analysis of the peripheral T-cell repertoire in kidney transplant patients. European Journal of Immunology, Wiley-VCH Verlag, 2010, 40 (11), pp.3280-3290. ⟨10.1002/eji.201040301⟩. ⟨hal-02664822⟩

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