Influence of subclinical inflammatory airway disease on equine respiratory function evaluated by impulse oscillometry - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Access content directly
Journal Articles Equine Veterinary Journal Year : 2009

Influence of subclinical inflammatory airway disease on equine respiratory function evaluated by impulse oscillometry

Abstract

Reasons for performing study: Inflammatory airway disease (IAD) is a nonseptic condition of the lower respiratory tract. Its negative impact on respiratory function has previously been described using either forced expiration or forced oscillations techniques. However, sedation or drug-induced bronchoconstriction were usually required. The impulse oscillometry system (IOS) is a noninvasive and sensitive respiratory function test validated in horses, which could be useful to evaluate IAD-affected horses without further procedures. Objectives: To determine the sensitivity of IOS in detecting alterations of the respiratory function in subclinically IAD-affected horses without inducing bronchoprovocation and to characterise their respiratory impedance according to frequency for each respiratory phase. Methods: Pulmonary function was evaluated at rest by IOS in 34 Standardbred trotters. According to the cytology of bronchoalveolar lavage fluid (BALF), 19 horses were defined as IAD-affected and 15 horses were used as control (CTL). Total respiratory resistance (Rrs) and reactance (Xrs) from 1-20 Hz as well as their inspiratory and expiratory components were compared between groups. Results: A significant increase of Rrs at the lower frequencies (R (1-10 Hz)) as well as a significant decrease of Xrs beyond 5 Hz (X(5-20 Hz)) was observed in IAD compared to CTL horses. IOS-data was also significantly different between inspiration and expiration in IAD-affected horses. In the whole population, both BALF eosinophil and mast cell counts were significantly correlated with IOS measurements. Conclusions: Functional respiratory impairment may be measured, even in the absence of clinical signs of disease. In IAD-affected horses, the different parameters of respiratory function (Rrs or Xrs) may vary depending on the inflammatory cell profiles represented in BALF. Potential relevance: Impulse oscillometry could be used in a routine clinical setting as a noninvasive method for early detection of subclinical respiratory disease and of the results of treatment in horses.

Dates and versions

hal-02664947 , version 1 (31-05-2020)

Identifiers

Cite

E.A. Richard, G.D. Fortier, Jean-Marie Denoix, T. Art, P.M. Lekeux, et al.. Influence of subclinical inflammatory airway disease on equine respiratory function evaluated by impulse oscillometry. Equine Veterinary Journal, 2009, 41 (4), pp.384-389. ⟨10.2746/042516409X366121⟩. ⟨hal-02664947⟩
11 View
0 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More