Spatio-temporal differences in the profile of murine brain expression of proinflammatory cytokines and indoleamine 2,3-dioxygenase in response to peripheral lipopolysaccharide administration - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Access content directly
Journal Articles Journal of Neuroimmunology Year : 2008

Spatio-temporal differences in the profile of murine brain expression of proinflammatory cytokines and indoleamine 2,3-dioxygenase in response to peripheral lipopolysaccharide administration

Abstract

The mechanisms underlying in vivo activation of indoleamine 2,3-dioxygenase (IDO), a tryptophan-catabolizing enzyme that mediates in the brain the induction of depressive-like behavior by peripheral innate immune system stimulation are still poorly understood. By monitoring how cytokines parallel IDO mRNA expression in the brain in response to intraperitoneal lipopolysaccharide injection in mice, we report a time-dependent induction of IDO expression in both the hippocampus and hypothalamus that was associated with a specific structure-dependent expression of proinflammatory cytokines, particularly interferon-γ. This study suggests that different mechanisms regulate the activation of IDO by lipopolysaccharide in various brain structures.

Dates and versions

hal-02665835 , version 1 (31-05-2020)

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Caroline Andre, Jason C. O'Connor, Keith W. Welley, Jacques Lestage, Robert Dantzer, et al.. Spatio-temporal differences in the profile of murine brain expression of proinflammatory cytokines and indoleamine 2,3-dioxygenase in response to peripheral lipopolysaccharide administration. Journal of Neuroimmunology, 2008, 200 (1-2), pp.90-99. ⟨10.1016/j.jneuroim.2008.06.011⟩. ⟨hal-02665835⟩

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