Transmission of Atypical Bovine Prions to Mice Transgenic for Human Prion Protein - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Access content directly
Journal Articles Emerging Infectious Diseases Year : 2008

Transmission of Atypical Bovine Prions to Mice Transgenic for Human Prion Protein

Abstract

To assess risk for cattle-to-human transmission of prions that cause uncommon forms of bovine spongiform encephalopathy (BSE), we inoculated mice expressing human PrP Met with fi eld isolates. Unlike classical BSE agent, L-type prions appeared to propagate in these mice with no obvious transmission barrier. H-type prions failed to infect the mice.
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hal-02667014 , version 1 (31-05-2020)

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Vincent Béringue, Laetitia Herzog, Fabienne Reine, Annick Le Dur, Cristina Casalone, et al.. Transmission of Atypical Bovine Prions to Mice Transgenic for Human Prion Protein. Emerging Infectious Diseases, 2008, 14 (12), pp.1898-1901. ⟨10.3201/eid1412.080941⟩. ⟨hal-02667014⟩
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