Transmission of Atypical Bovine Prions to Mice Transgenic for Human Prion Protein
Abstract
To assess risk for cattle-to-human transmission of prions that cause uncommon forms of bovine spongiform encephalopathy (BSE), we inoculated mice expressing human PrP Met with fi eld isolates. Unlike classical BSE agent, L-type prions appeared to propagate in these mice with no obvious transmission barrier. H-type prions failed to infect the mice.
Domains
Life Sciences [q-bio]| Origin | Publisher files allowed on an open archive |
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