Skip to Main content Skip to Navigation
Journal articles

A comparative genome approach to marker ordering

Abstract : Motivation: Genome maps are fundamental to the study of an organism and essential in the process of genome sequencing which in turn provides the ultimate map of the genome. The increased number of genomes being sequenced offers new opportunities for the mapping of closely related organisms. We propose here an algorithmic formalization of a genome comparison approach to marker ordering. Results: In order to integrate a comparative mapping approach in the algorithmic process of map construction and selection, we propose to extend the usual statistical model describing the experimental data, here radiation hybrids (RH) data, in a statistical framework that models additionally the evolutionary relationships between a proposed map and a reference map: an existing map of the corresponding orthologous genes or markers in a closely related organism. This has concretely the effect of exploiting, in the process of map selection, the information of marker adjacencies in the related genome when the information provided by the experimental data is not conclusive for the purpose of ordering. In order to compute efficiently the map, we proceed to a reduction of the maximum likelihood estimation to the Traveling Salesman Problem. Experiments on simulated RH data sets as well as on a real RH data set from the canine RH project show that maps produced using the likelihood defined by the new model are significantly better than maps built using the traditional RH model.
Document type :
Journal articles
Complete list of metadata

https://hal.inrae.fr/hal-02667668
Contributor : Migration Prodinra Connect in order to contact the contributor
Submitted on : Sunday, May 31, 2020 - 11:09:56 AM
Last modification on : Tuesday, October 19, 2021 - 2:24:22 PM

Links full text

Identifiers

Citation

Thomas Faraut, Simon de Givry, Patrick Chabrier, Thomas Derrien, Francis Galibert, et al.. A comparative genome approach to marker ordering. Bioinformatics, Oxford University Press (OUP), 2007, 23 (2), pp.E50-E56. ⟨10.1093/bioinformatics/btl321⟩. ⟨hal-02667668⟩

Share

Metrics

Record views

22