Nod2 mediates susceptibility to <em>Yersinia pseudotuberculosis</em> in mice - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement
Article Dans Une Revue PLoS ONE Année : 2008

Nod2 mediates susceptibility to Yersinia pseudotuberculosis in mice

Résumé

Nucleotide oligomerisation domain 2 (NOD2) is a component of the innate immunity known to be involved in the homeostasis of Peyer patches (PPs) in mice. However, little is known about its role during gut infection in vivo. Yersinia pseudotuberculosis is an enteropathogen causing gastroenteritis, adenolymphitis and septicaemia which is able to invade its host through PPs. We investigated the role of Nod2 during Y. pseudotuberculosis infection. Death was delayed in Nod2 deleted and Crohn’s disease associated Nod2 mutated mice orogastrically inoculated with Y. pseudotuberculosis. In PPs, the local immune response was characterized by a higher KC level and a more intense infiltration by neutrophils and macrophages. The apoptotic and bacterial cell counts were decreased. Finally, Nod2 deleted mice had a lower systemic bacterial dissemination and less damage of the haematopoeitic organs. This resistance phenotype was lost in case of intraperitoneal infection. We concluded that Nod2 contributes to the susceptibility to Y. pseudotuberculosis in mice.
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Dates et versions

hal-02667796 , version 1 (31-05-2020)

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Ulrich Meinzer, Sophie Esmiol-Welterlin, Frederick Barreau, Dominique Berrebi, Monique Dussaillant, et al.. Nod2 mediates susceptibility to Yersinia pseudotuberculosis in mice. PLoS ONE, 2008, 3 (7), pp.e2769. ⟨10.1371/journal.pone.0002769⟩. ⟨hal-02667796⟩
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