Skip to Main content Skip to Navigation
Journal articles

Role of bacteria in the etiopathogenesis of inflammatory bowel disease

Abstract : Increased numbers of mucosa-associated Escherichia coli are observed in both of the major inflammatory bowel diseases, Crohn's disease (CD) and ulcerative colitis (UC). A potential pathophysiological link between the presence of pathogenic invasive bacteria and genetic host susceptibility of patients with ileal CD is suspected. In CD patients, with increased ileal expression of the CEACAM6 molecule acting as a receptor recognized by type I pilus bacterial adhesin, and with the identification of mutations in the NOD2-encoding gene, the presence of pathogenic invasive bacteria could be the link between abnormal ileal bacterial colonization and innate immune responses to invasive bacteria. In a susceptible host, the sequential etiological steps of the disease induced by adherent-invasive E. coli (AIEC) are: (1) abnormal colonization via binding to the CEACAM6 receptor, which is overexpressed in the ileal mucosa of CD patients; (2) ability to adhere to and to invade intestinal epithelial cells, which allows bacteria to cross the mucosal barrier; (3) survival and replication within infected macrophages in the lamina propria; and (4) induction of tumor necrosis factor-alpha secretion and granuloma formation.
Document type :
Journal articles
Complete list of metadata

Cited literature [40 references]  Display  Hide  Download
Contributor : Migration ProdInra Connect in order to contact the contributor
Submitted on : Sunday, May 31, 2020 - 2:25:01 PM
Last modification on : Friday, June 12, 2020 - 10:43:26 AM


Publisher files allowed on an open archive


  • HAL Id : hal-02669138, version 1
  • PRODINRA : 14642
  • WOS : 000250232400004



Nicolas Barnich, Arlette Darfeuille-Michaud. Role of bacteria in the etiopathogenesis of inflammatory bowel disease. World Journal of Gastroenterology, Baishideng Publishing Group Co. Limited, 2007, 13 (42), pp.5571-5576. ⟨hal-02669138⟩



Record views


Files downloads