Contrast enhancement in atherosclerosis development in a mouse model : in vivo results at 2 Tesla - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Access content directly
Journal Articles Magnetic Resonance Materials in Physics, Biology and Medicine Year : 2004

Contrast enhancement in atherosclerosis development in a mouse model : in vivo results at 2 Tesla

Abstract

To develop an MRI method for the evaluation of contrast enhancement in early atherosclerotic plaque development in the abdominal aorta of a mouse model. Male apoE(-/-) mice from three groups, respectively 4 (n = 6), 8 (n = 11) and 16 (n = 4) weeks were included. Axial T I spin echo images of the abdominal aorta were obtained above and below the renal arteries (90 mu m spatial resolution) before and over 1 h after the injection of a macromolecular contrast agent. Signal enhancement was measured in the vessel wall and compared to histological features. Maximal arterial wall signal enhancement was obtained from 16 to 32 min post injection. During this time, the signal-to-noise ratio increased by a factor up to 1.7 in 16 week mice and 2.7 and 2.4 in 8 and 4 weeks mice, respectively. The enhancement of the arterial wall appeared less pronounced in the oldest mice, 16 weeks old, exhibiting more advanced lesions. Using a macromolecular gadolinium agent, contrast uptake in atherogenesis varies with lesion stage and may be related to vessel-wall permeability. Dynamic contrast-enhanced MRI may be useful to evaluate the atherosclerotic plaque activity in mice.

Dates and versions

hal-02675496 , version 1 (31-05-2020)

Identifiers

Cite

L. Chaabane, N. Pellet, M.C. Bourdillon, C.D. Mansard, A. Sulaiman, et al.. Contrast enhancement in atherosclerosis development in a mouse model : in vivo results at 2 Tesla. Magnetic Resonance Materials in Physics, Biology and Medicine, 2004, 17 (3-6), pp.188-195. ⟨10.1007/s10334-004-0055-7⟩. ⟨hal-02675496⟩
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