Prevention of patulin toxicity on rumen microbial fermentation by SH-containing reducing agents - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement
Article Dans Une Revue Journal of Agricultural and Food Chemistry Année : 2003

Prevention of patulin toxicity on rumen microbial fermentation by SH-containing reducing agents

Résumé

Patulin, a toxic fungal metabolite, negatively affects rumen fermentation. This mycotoxin has also been associated with intoxication cases in cattle. This study investigates the use of SH-containing reducing compounds to prevent patulin's negative effects on the rumen microbial ecosystem. The effect of 50 mug/mL patulin on the fermentation of alfalfa hay was measured in batch cultures with and without reducing agents. Sulfhydryl-containing cysteine and glutathione prevented the negative effects of the toxin on dry matter degradation, gas, and volatile fatty acid production (P < 0.01). However, non-sulfhydryl-containing ascorbic and ferulic acids did not protect against patulin's toxicity (P > 0.01). Patulin was unstable in buffered rumen fluid as the concentration decreased by half after 4 h of incubation. In the presence of sulfhydryl groups, the toxin disappeared rapidly and was not detected after 1 h of incubation. The utilization of sulfhydryl-containing compounds such as cysteine to avert patulin toxicity could have practical implications in ruminant nutrition.

Dates et versions

hal-02678505 , version 1 (31-05-2020)

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Citer

Diego Morgavi, Hamid Boudra, J.P. Jouany, Dominique Graviou. Prevention of patulin toxicity on rumen microbial fermentation by SH-containing reducing agents. Journal of Agricultural and Food Chemistry, 2003, 51 (23), pp.6906-6910. ⟨10.1021/jf034505v⟩. ⟨hal-02678505⟩

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