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Article Dans Une Revue Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. Année : 2004

Up date on IGFBP-4: regulation of IGFBP-4 levels and functions, in vitro and in vivo.

Résumé

Of the six known high affinity insulin-like growth factor binding-proteins (IGFBPs), IGFBP-4 appears to be unique in that it is the only IGFBP that functions mostly like a traditional binding protein. In this regard, none of the IGF independent effects that have been ascribed for other IGFBPs have been described for IGFBP-4. However, recent in vitro and in vivo studies, in particular the recent identification of pregnancy-associated plasma protein-A as a major IGFBP-4 protease, are consistent with the idea that IGFBP-4 is an extremely important component of IGF system in several tissues including gonads and bone. In this review, we have provided an update on IGFBP-4 research and we have summarized our current understanding of the regulation of levels and actions of IGFBP-4 and proteolytic fragments both in vitro and in vivo.

Dates et versions

hal-00086349 , version 1 (18-07-2006)

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Citer

Sabine Mazerbourg, Isabelle Callebaut, Jürgen Zapf, Subburaman Mohan, Michael Overgaard, et al.. Up date on IGFBP-4: regulation of IGFBP-4 levels and functions, in vitro and in vivo.. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society., 2004, 14, pp.71-84. ⟨10.1016/j.ghir.2003.10.002⟩. ⟨hal-00086349⟩
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