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Serine/threonine protein phosphatases PP1 and PP2A are key players in apoptosis

Abstract : The reversible phosphorylation of proteins controlled by protein kinases and protein phosphatases is a major mechanism that regulates a wide variety of cellular processes. In contrast to C. elegans, recent studies in mammalian cells have highlighted a major role of serine/threonine protein phosphorylation in apoptosis. To illustrate the importance of dephosphorylation processes in apoptosis, this review will focus on recent studies suggesting that the interaction of the serine/threonine protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) with certain regulators of the Bcl-2 family is critically involved in the control of apoptosis.
Keywords : Apoptosis PP1 PP2A Bcl-2 Bad
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Submitted on : Sunday, May 31, 2020 - 10:30:00 PM
Last modification on : Friday, May 6, 2022 - 2:22:10 PM

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Alphonse Garcia, Xavier Cayla, Julien Guergnon, Frederic Dessauge, Véronique Hospital, et al.. Serine/threonine protein phosphatases PP1 and PP2A are key players in apoptosis. Biochimie, Elsevier, 2003, 85 (8), pp.721-726. ⟨10.1016/j.biochi.2003.09.004⟩. ⟨hal-02680625⟩

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