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Induction of partial protection in mice after oral administration of Lactococcus lactis producing Brucella abortus L7/L12 antigen.

Abstract : The Brucella abortus ribosomal protein L7/L12 is an immunodominant antigen and an interesting candidate for the development of oral live vaccines against brucellosis. Here, a recombinant Lactococcus lactis strain producing L7/L12 under the control of nisin inducible promoter was orally administered to BALB/c mice. Significant levels of anti-L7/L12 specific IgA detected in feces revealed an induced local humoral immune response. However, serum analysis did not reveal any anti-L7/L12 antibodies suggesting the absence of a systemic response. Nevertheless, the vaccinated mice showed a partial protective immunity against B. abortus virulent strain (S2308) challenged by intraperitoneal inoculation.
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https://hal.inrae.fr/hal-02683037
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Submitted on : Monday, June 1, 2020 - 2:14:50 AM
Last modification on : Tuesday, September 7, 2021 - 3:34:10 PM

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Daniela S Pontes, Fernanda A Dorella, Luciana A Ribeiro, Anderson Miyoshi, Yves Le Loir, et al.. Induction of partial protection in mice after oral administration of Lactococcus lactis producing Brucella abortus L7/L12 antigen.. Journal of Drug Targeting, Informa Healthcare, 2003, 11 (8-10), pp.489-493. ⟨10.1080/10611860410001670035⟩. ⟨hal-02683037⟩

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