Recurrent recruitment of the THAP DNA-binding domain and molecular domestication of the P-transposable element - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Access content directly
Journal Articles Molecular Biology and Evolution Year : 2005

Recurrent recruitment of the THAP DNA-binding domain and molecular domestication of the P-transposable element

Abstract

The recently described THAP domain motif characterizes a DNA-binding domain (DBD) that is widely conserved in human and in animals. It presents a similarity with the DBD of the P element transposase of D. melanogaster. We show here that the P Drosophila neogenes derived from P-transposable elements conserve the THAP domain. Moreover, secondary rearrangements by exon shuffling indicate the recurrent recruitment of this domain by the host genome. As P sequences and THAP genes are found together in many animal genomes, we discuss the possibility that the THAP proteins have acquired their domain as a result of recurrent molecular domestication of P-transposable elements.

Dates and versions

hal-02683097 , version 1 (01-06-2020)

Identifiers

Cite

Hadi Quesneville, D Nouaud, D Anxolabéhère. Recurrent recruitment of the THAP DNA-binding domain and molecular domestication of the P-transposable element. Molecular Biology and Evolution, 2005, 22 (3), pp.741-746. ⟨10.1093/molbev/msi064⟩. ⟨hal-02683097⟩
9 View
0 Download

Altmetric

Share

Gmail Facebook X LinkedIn More