Skip to Main content Skip to Navigation
Journal articles

Juxtaposed microsatellite systems as diagnostic markers for admixture : Theoretical aspects

Abstract : Two populations which have diverged from an ancestral population may come back into contact due to humanaction via stocking or introduction programs. We report here a method to measure genetic admixture in such situations based on juxtaposed microsatellite systems (JMSs). A JMS is composed of two microsatellite repeatarrays separated by a sequence of less than 200 bp. The advantage of a JMS stems from the superior genealogical information carried by the two microsatellite sites to that carried by just one. If five assumptions are fulfilled, JMSs provide reliable diagnostic markers which eliminate the need to know the genetic structure of the native population in the absence of admixture. Simulations show that optimal features at both microsatellite sites of the JMS are theoccurrence of multistep mutations, moderately high mutation rates, and limited allele size constraints. Optimal demographic features include a relatively large number of generations since the separation of the alien and native populations and small population sizes, especially for the alien population. Substantial sampling of the alien population is also necessary
Document type :
Journal articles
Complete list of metadata
Contributor : Migration Prodinra <>
Submitted on : Wednesday, June 16, 2021 - 11:03:16 AM
Last modification on : Thursday, June 17, 2021 - 3:44:17 AM


Publisher files allowed on an open archive


Distributed under a Creative Commons Attribution 4.0 International License


  • HAL Id : hal-02688919, version 1
  • PRODINRA : 53506


Arnaud Estoup, Jean-Marie Cornuet, François Rousset, René Guyomard. Juxtaposed microsatellite systems as diagnostic markers for admixture : Theoretical aspects. Molecular Biology and Evolution, Oxford University Press (OUP), 1999, 16 (7), pp.898-908. ⟨hal-02688919⟩



Record views


Files downloads