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Mouse 5-HT2B receptor-mediated serotonin trophic functions.

Abstract : 5-HT2B receptors, in addition to phospholipase C stimulation, are able to trigger activation of the proto-oncogene product p21ras. During mouse embryogenesis, a peak of 5-HT2B receptor expression is detected at the neurulation stage; we localized the 5-HT2B expression in neural crest cells, heart myocardium, and somites. The requirement for functional 5-HT2B receptors shortly after gastrulation, is supported by culture of embryos exposed to 5-HT2B-high affinity antagonist such as ritanserin, which induces morphological defects in the cephalic region, heart and neural tube. Functional 5-HT2B receptors are also expressed during the serotonergic differentiation of the mouse F9 teratocarcinoma-derived clonal cell line 1C11. Upon 2 days of induction by cAMP, 5-HT2B receptors become functional, and on day 4, the appearance of 5-HT2A receptors coincides with the onset of active serotonin transporter by these cells. Active serotonin uptake is modulated by serotonin suggesting autoreceptor functions for 5-HT2B receptors.
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https://hal.inrae.fr/hal-02693974
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Submitted on : Monday, June 1, 2020 - 7:57:11 AM
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D S Choi, Odile Kellermann, S Richard, J F Colas, Francisco Bolaños-Jiménez, et al.. Mouse 5-HT2B receptor-mediated serotonin trophic functions.. Annals of the New York Academy of Sciences, Wiley, 1998, 861, pp.67-73. ⟨10.1111/j.1749-6632.1998.tb10174.x⟩. ⟨hal-02693974⟩

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