Structure and developmental expression of mouse Garp, a gene encoding a new leucine-rich repeat-containing protein - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Access content directly
Journal Articles International Journal of Developmental Biology Year : 1996

Structure and developmental expression of mouse Garp, a gene encoding a new leucine-rich repeat-containing protein

Abstract

Proteins with leucine-rich repeats (LRR) constitute a large family of molecules playing a role in protein-protein interactions and signal transduction. They are involved in various cellular processes in different species. We characterized the organization and pattern of expression of the mouse Garp gene. It is composed of two coding exons, expressed as a major 4.3 kb mRNA, and encodes a putative LRR transmembrane protein with an extracellular region almost entirely made of 20 repeats, and a short intracytoplasmic region. The mouse GARP deduced amino-acid sequence is highly similar to that of the human protein. The Garp gene is expressed in various areas in the mid-gestation developing embryo, including skin, lens fibre cells, nasal cavity, smooth and skeletal muscles, lung, and megakaryocytes of the fetal liver. In the adult it is expressed in the megakaryocytes of the spleen and in endothelial cells of the placenta. The data suggests that GARP might be involved in platelet-endothelium interactions.
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Dates and versions

hal-02694026 , version 1 (01-06-2020)

Identifiers

  • HAL Id : hal-02694026 , version 1
  • PRODINRA : 441923
  • PUBMED : 8840187
  • WOS : A1996UY78100004

Cite

Regine Roubin, Sandrine Pizette, Vincent Ollendorff, Jacqueline Planche, Daniel Birnbaum, et al.. Structure and developmental expression of mouse Garp, a gene encoding a new leucine-rich repeat-containing protein. International Journal of Developmental Biology, 1996, 40 (3), pp.545-555. ⟨hal-02694026⟩

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