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Preferential expression of 5-HT1D over 5-HT1B receptors during early embryogenesis.

Abstract : The cloning and pharmacological characterization of mouse 5-HT1D receptors as well as the comparative analysis of its embryonic expression vs that of 5-HT1B receptors are reported. High densities of both 5-HT1D receptors mRNA and specific 5-HT1D binding sites were detected at 8, 9.5, 10.5 and 13.5 days of prenatal development. In contrast, no specific 5-HT1B binding sites could be detected until 13.5 days of development, when they were present at lower levels than 5-HT1D receptors. This differs markedly from the situation in the adult brain, in which 5-HT1B receptors are present at a much higher density than the 5-HT1D subtype. These data suggest the involvement of 5-HT1D receptors in the mitogenic and proliferative effects of serotonin during early embryonic development.
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Francisco Bolaños-Jiménez, D S Choi, L Maroteaux. Preferential expression of 5-HT1D over 5-HT1B receptors during early embryogenesis.. NeuroReport, Lippincott, Williams & Wilkins, 1997, 8 (17), pp.3655-3660. ⟨10.1097/00001756-199712010-00001⟩. ⟨hal-02696479⟩



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