HAL will be down for maintenance from Friday, June 10 at 4pm through Monday, June 13 at 9am. More information
Skip to Main content Skip to Navigation
Journal articles

Vitamin A contained in the lipid droplets of rat liver stellate cells is substrate for acid retinyl ester hydrolase.

Abstract : Vitamin A is stored in the lipid droplets of liver stellate cells (LSCs), as retinyl esters whose hydrolysis is necessary for the secretion of retinol into the blood. Here, we isolated these retinyl esters under their physiological form, i.e., in LSC lipid droplets, which had retained their morphological and biochemical characteristics. These retinyl esters are substrate for an hydrolytic enzyme, whose optimum pH is 4.1, and which is kinetically similar to the acidic retinyl ester hydrolase (aREH) we had previously described (Mercier et al., Biochim. Biophys. Acta (1994) 1212, 176-182). The cellular and subcellular localizations of aREH activity in rat liver suggest that this enzyme could be involved in the hydrolysis of the esterified vitamin A stores.
Document type :
Journal articles
Complete list of metadata

https://hal.inrae.fr/hal-02713862
Contributor : Migration Prodinra Connect in order to contact the contributor
Submitted on : Monday, June 1, 2020 - 7:15:16 PM
Last modification on : Tuesday, June 15, 2021 - 11:16:04 AM

Links full text

Identifiers

Collections

Citation

Véronique Azaïs-Braesco, Isabelle Dodeman, Serge Delpal, Marie Cécile Alexandre-Gouabau, Anne Partier, et al.. Vitamin A contained in the lipid droplets of rat liver stellate cells is substrate for acid retinyl ester hydrolase.. BBA - Biochimica et Biophysica Acta, Elsevier, 1995, 1259 (3), pp.271-276. ⟨10.1016/0005-2760(95)00173-5⟩. ⟨hal-02713862⟩

Share

Metrics

Record views

2