Psychoneuroendocrine profile associated with hypertension or hyperactivity in spontaneously hypertensive rats - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Access content directly
Journal Articles AJP - Regulatory, Integrative and Comparative Physiology Year : 1993

Psychoneuroendocrine profile associated with hypertension or hyperactivity in spontaneously hypertensive rats

Abstract

We studied the dural plasma protein extravasation response after unilateral electrical stimulation of the trigeminal ganglion in mice lacking serotonin 5-HT1B (5-HT1D beta) receptors by modifying a technique previously described in rats or guinea pigs. We investigated the inhibitory effects of six 5-HT1 receptor agonists in this model: 3-(1,2,5,6-tetrahydropyrid-4-yl)pyrrolo[3,2-b]pyrid-5-one (CP-93,129), sumatriptan, serotonin-5-O-carboxymethylglycyl-tyrosinamide (GTI), 5-methylaminosulfonylmethyl-3-(N-methylpyrrolidin-2R-ylmethyl)-1H-indole (CP-122,288), 5-carboxamido-tryptamine (5-CT), and dihydroergotamine. The plasma extravasation response did not differ between wild-type and mutant after vehicle injection. The potency of sumatriptan, CP-122,288, CP-93,129, and 5-CT in wild-type mice was similar to that previously reported for rats. CP-122,288 (1 nmol kg), 5-CT (1 nmol/kg), and dihydroergotamine (72 nmol/kg) inhibited plasma protein extravasation within dura mater after electrical trigeminal ganglion stimulation in both wild-type and knockout mice, which suggests that these agonists act predominantly via receptors other than 5-HT1B. Unlike in wild-type mice, CP-93,129 (1.4 mu mol/kg), a specific 5-HT1B receptor agonist, had no effect in knockout mice. The same held true for sumatriptan (0.7 mu mol/kg) and GTI (0.6 mu mol/kg). These results suggest that CP-93,129, sumatriptan, and GTI exert their effects via 5-HT1B (5-HT1D beta) receptors in mice.

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hal-02714722 , version 1 (01-06-2020)

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Nathalie Castanon, E.D. Hendley, X.M. Fan, Pierre Mormède. Psychoneuroendocrine profile associated with hypertension or hyperactivity in spontaneously hypertensive rats. AJP - Regulatory, Integrative and Comparative Physiology, 1993, 265 (6), pp.R1304-R1310. ⟨10.1152/ajpregu.1993.265.6.R1304⟩. ⟨hal-02714722⟩

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