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Assignment of the rat genes coding for DOPA decarboxylase (DDC) and glutamic acid decarboxylases (GAD1 and GAD2)

Abstract : By use of rat cDNA probes and a panel of cell hybrids segregating rat chromosomes, the genes encoding three pyridoxal 5'-phosphate (PLP)-dependent decarboxylases-namely, DOPA-decarboxylase (Ddc), glutamic acid decarboxylase 1 and 2 (Gad1 and Gad2)-were assigned to rat Chromosomes (Chrs) 14, 3, and 17, respectively. If one takes into account chromosome localizations in the human and the mouse, the present results (i) show that a synteny group is retained on rat Chr 14, human Chr 7, and mouse Chr 11 (Ddc); (ii) strengthen the homology relation known between rat Chr 3 and human and mouse Chrs 2 (Gad1); (iii) suggest that rat Chr 17 has no extensive homology to any human chromosome; and (iv) suggest the order (Prl, Fdp)-Tpl2-Gad2 on the rat Chr 17.
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https://hal.inrae.fr/hal-02715991
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Submitted on : Monday, June 1, 2020 - 8:35:27 PM
Last modification on : Tuesday, October 19, 2021 - 12:55:42 PM

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Cécile Vassort, Michel Rivière, Gilles Bruneau, François Gros, Jean Thibault, et al.. Assignment of the rat genes coding for DOPA decarboxylase (DDC) and glutamic acid decarboxylases (GAD1 and GAD2). Mammalian Genome, Springer Verlag, 1993, 4 (4), pp.202-206. ⟨10.1007/BF00417563⟩. ⟨hal-02715991⟩

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