Skip to Main content Skip to Navigation
Journal articles

Intestinal transfer of growth hormone into the circulatory system of the rainbow trout,Salmo gairdneri: Interference by granule cells

Abstract : To test if growth hormone, well known for its strong effect on fish growth, could be incorporated into the diet, bovine growth hormone (bGH) was introduced into the lumen of the digestive tract of trout yearling (Salmo gairdneri). Radioimmunoassay (RIA) and radioreceptorassay (RRA) were used to assess plasma concentration of bGH. In our experimental conditions, the concentration of bGH peaks after 1 hour, in treated fish only, attesting to the intestinal hormone transfer (coefficient of absorption is about 0.2%). Immunocytochemistry is used to follow the hormone transfer process. Most bGH molecules absorbed by enterocytes of the distal segment are found in the vacuoles (phagolysosomes) of the apical hyaloplasm. A small part escapes the intracellular degradation and is found in the intercellular space and in the interstitial space of the lamina propria. At this level, the granule cells trapped the antigenic hormone, as did immune cells. The results of this study indicate that oral administration of GH can be potentially used in fish culture.
Document type :
Journal articles
Complete list of metadata

Cited literature [46 references]  Display  Hide  Download

https://hal.inrae.fr/hal-02728126
Contributor : Migration Prodinra <>
Submitted on : Tuesday, June 2, 2020 - 3:40:12 AM
Last modification on : Thursday, December 10, 2020 - 6:48:08 PM

File

Leba1989JEZ_1.pdf
Publisher files allowed on an open archive

Identifiers

Collections

Citation

Pierre-Yves Le Bail, Marie-France Sire, Jean-Marie Vernier. Intestinal transfer of growth hormone into the circulatory system of the rainbow trout,Salmo gairdneri: Interference by granule cells. Journal of Experimental Zoology, Wiley, 1989, 251 (1), pp.101-107. ⟨10.1002/jez.1402510112⟩. ⟨hal-02728126⟩

Share

Metrics

Record views

55

Files downloads

72