Induction of ovulation in goldfish, Carassius auratus by pimozide and analogues of LH-RH - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Accéder directement au contenu
Article Dans Une Revue Aquaculture Année : 1984

Induction of ovulation in goldfish, Carassius auratus by pimozide and analogues of LH-RH

Résumé

The effects of intraperitoneal injections or pellet implantations of luteinizing hormone-releasing hormone analogues, des-Gly10-[D-ALA6]-LH-RH-ethylamide (LRH-Aa) or des-Gly10-[D-Trp6]-LH-RH-ethylamide (LRH-At), respectively, and the combination of these treatments with pimozide, a dopamine antagonist, on serum gonadotropin (GtH) and ovulation in goldfish held at 18–20°C were investigated. Injections of LRH-Aa (0.1 μg/g body weight) or pellet implants of LRH-At (25 and 125 μg/fish) alone increased serum GtH levels, but were relatively ineffective for inducing ovulation in goldfish (≅ 25% rate of occurrence). Pimozide greatly potentiated the GtH release response to LRH-Aa injections or LRH-At pellet implantations. A high rate of occurrence of ovulation (87%) was observed within 24 h when pimozide was injected prior to or with the first of two injections of LRH-Aa, or following implantations of LRH-At pellets that give continuous release of LRH-At. These results are consistent with the idea that dopamine acts directly at the pituitary level as a GtH release-inhibitory factor in goldfish.

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hal-02728616 , version 1 (02-06-2020)

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M. Sokolowska, R.E. Peter, C.S. Nahorniak, C.H. Pan, J.P. Chang, et al.. Induction of ovulation in goldfish, Carassius auratus by pimozide and analogues of LH-RH. Aquaculture, 1984, 36, pp.71-83. ⟨10.1016/0044-8486(84)90055-3⟩. ⟨hal-02728616⟩

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