Joint estimation of effective population size and selection coefficient without neutrel markers: method validation and application to experimental evolution of viruses
Résumé
Experimental evolution studies deserve considerable attention to the estimation of basic evolutionary forces such as selection and genetic drift. With the advent of high-throughput sequencing techniques, these studies gained a renewed attention. However the joint estimation of selection and genetic drift still remain challenging when no neutral markers are available, a common situation with many microbes, such as viruses, due to their small tightly packed genomes.
Domaines
Sciences agricoles
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Palloix 13.int. plant virus epid. sympo. 2016 16_1.pdf (1.78 Mo)
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