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Poster communications

Does early pregnancy influence maternal metabolism in dairy heifers?

Abstract : It is known that changes of sexual steroid hormones during cycle and early pregnancy affect maternal metabolism. But when do embryo-factors start to take influence? The aim was to investigate metabolic changes in cattle already on Day 18. Blood samples of Holstein Friesian heifers (n=30) were taken on Day 0 (Day of ovulation), 7, 14, 16 and 18 in repeated consecutive pregnant and non-pregnant periods. Concentrations of progesterone (P4[ng/ml]), estrogens (E), insulin, insulin-like-growth-factors (IGF-I+IGF-II), triiodothyronine (T3) and thyroxine (T4) were determined. Heifers were defined as pregnant (D18=P4>2.0 and either recovery of conceptus on D18(n=12) or embryonic heart beat on D42 (n=21) [PP4; n=33]) and non-pregnant (D18=P4<2.0 and no conceptus [NP4;n=59]). In several non-pregnant heifers P4 remained high, whichled to the third group (D18=P4>2.0 and no conceptus [NP4;n=9]). Insulin, IGF-I, IGF-II, T3 and T4 blood levels were similar between the three groups at D18. In all groups IGF-I decreased from D0 to D16 (p<0.001) whereas IGF-II increased (p<0.01). Unexpectedly, IGF-I levels increased from D16 to D18 in the diverse groups PP4 and NP4 (p<0.05) but remained stable in NP4. T4 and T3 levels decreased from D0 to D14 and from D0 to D18 respectively in PP4 and NP4(p<0.05). In conclusion the present data confirm literature concerning the fact, that IGF-I increases during estrus. However, despite inverse sexual steroid hormone influence, pregnant heifers showed the same increase in IGF-I towards D18 as non-pregnant heifers with low P4. These observations indicate that in early pregnant heifers IGF-I blood levels might be independent from steroid balance, suggesting that other signals including embryo factors may regulate the production of this growth factor.
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Poster communications
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https://hal.inrae.fr/hal-02741051
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Submitted on : Wednesday, June 3, 2020 - 12:29:38 AM
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M. Meyerholz, K. Mense, M. Steufmehl, A. Kassens, Mariam Raliou, et al.. Does early pregnancy influence maternal metabolism in dairy heifers?. 47. Annual Conference of Physiology and Pathology of Reproduction, 39. Joint Conference on Veterinary and Human Reproductive Medicine, Feb 2014, Giessen, Germany. Wiley Online Library, Reproduction in Domestic Animals, 49 (supplement 1), 52 p., 2014, 47th Annual Conference of Physiology and Pathology of Reproduction, 39th Joint Conference on Veterinary and Human Reproductive Medicine. ⟨10.1111/rda.12292⟩. ⟨hal-02741051⟩

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