GPR40 limits bone loss induced by ovariectomy upon high fat diet
Résumé
We formerly demonstrated that GPR40 prevents from osteoporosis establishment using synthetic agonist. Here, we questioned whether stimulation of GPR40 by fatty acids, the natural ligands for GPR40, may parallel with its described beneficial effects on bone. In this study we demonstrated for the first time that GPR40 limits bone loss induced by ovariectomy upon high fat diet. Taken together, our results demonstrate that GPR40 mediates beneficial effects of high fat diets mainly by targeting the bone cell coupling and subsequent osteoclastic bone resorption.
Domaines
Sciences du Vivant [q-bio]
Origine : Fichiers produits par l'(les) auteur(s)
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