Within the last decade, fMRI data in humans had point out the critical role of the hedonic component in the control of food intake. Taken into account the massive knowledge existing on the importance of the hypothalamus on virtually the same target i.e. weight control, it has been postulated that food intake was under the control of two independent networks: the hedonic and the homeostatic networks. Recent data obtained using functional imaging in humans and in animals models suggests that the situation is more complex. First non painful gastric distension mimicking that occurring immediately after the meal is not only able to activate nuclei directly associated to ascendant projections from the dorsal vagal complex but also limbic areas including prefrontal and orbito-frontal cortices. Second, we recently demonstrated that both duodenal and portal glucose infusions activated the dorsolateral prefrontal cortex and the primary somatosensory cortex. Third, Wang team has demonstrated in some obese individuals a decreased activity of the prefrontal cortex. We have showed using a large animal model, that this decreased activity is an acquire feature of obesity and not a pre-existent item. All these data militates in favour of a single network that process homeostatic and hedonic data.