A minimal and dynamic model for fatty acid metabolism in mouse liver
Résumé
We propose a modelling strategy to determine from a large set of reactions the smallest set necessary to be compatible with a compendium of required properties and experimental data. We applied this strategy to define a model of hepatic fatty acid metabolism integrating both metabolic pathways and the contribution of some major genetic regulators. We considered the fatty acid metabolism in hepatic cells of mice during a 72 hours fed-to-fast transition and we tested the key role of oxidation and elongation in fatty acid metabolism
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