Accéder directement au contenu Accéder directement à la navigation
Communication dans un congrès

Pharmacokinetic/Pharmacodynamic Assessment of irrelevant drug concentrations in horse plasma or urine for a selection of drugs

Abstract : The lower limits of detection of the analytical techniques currently used for drug testing in horses result in the dilemma of whether or not to report trace levels of drugs legitimately used for therapeutic medication. A non-experimental pharmacokinetic/pharmacodynamic approach for the determination of irrelevant drug plasma concentrations (IPC) and irrelevant urine concentrations (IUC) has been put forward by Toutain and Lassourd (2002). The published plasma clearance is used to transform an effective dose into an effective concentration (EPC). EPC is then transformed into an IPC by applying a safety factor (SF). This method is based on several assumptions ( eg drug effects reversibly driven by plasma concentration, linearity of drug disposition). To explore the feasibility and attractiveness of this approach, this article reports EPC, IPC and IUC for a selection of drugs.
Type de document :
Communication dans un congrès
Liste complète des métadonnées

https://hal.inrae.fr/hal-02761164
Déposant : Migration Prodinra <>
Soumis le : jeudi 4 juin 2020 - 05:33:29
Dernière modification le : vendredi 12 juin 2020 - 10:43:26

Fichier

44925_20110105123057335_1.pdf
Fichiers produits par l'(les) auteur(s)

Identifiants

  • HAL Id : hal-02761164, version 1
  • PRODINRA : 44925

Collections

Citation

Pierre-Louis Toutain, V. Lassourd. Pharmacokinetic/Pharmacodynamic Assessment of irrelevant drug concentrations in horse plasma or urine for a selection of drugs. Proceedings of the 14th International Conference of Racing Analysts and Veterinarians: Orlando, Florida, USA, 2002, Orlando, United States. ⟨hal-02761164⟩

Partager

Métriques

Consultations de la notice

22

Téléchargements de fichiers

11