The management of Potato virus Y (PVY) in potato crops poses a con-tinual challenge due to the non-persistent mode of transmission of the virus and the propagation of seed potato tubers over several generations in the field. While PVY- resistant cultivars remain the most efficient way to protect potato crops against PVY, a vast majority of cultivars grown do not display significant resistance to PVY. Due to the short time period for PVY transmission by non-colonising aphid vectors, efficient control of PVY relies on preventing aphids landing on a crop and on adopting precautionary measures by ensuring that crops are grown in areas of low aphid and low virus pressure and limiting field generation. Prophylactic mea-sures such as roguing and early haulm destruction limit PVY spread but are not efficient alone. Among all existing control methods, spraying potato crops with mineral oils can offer significant protection against PVY spread, but their efficacy do vary in field conditions. The combination of several control methods such as mineral oil treatments, crop borders, intercropping, straw mulching or insecticide treatments can increase protection. These emphasise the importance of controlling virus through appropriate monitoring methods and crop management enforced by seed certification schemes through the use of ‘clean’ input seed and, when possible, the segregation of seed and ware crops to minimise the risk of virus transmission. This chapter presents and discusses the most widely used techniques of control and management of PVY, their effectiveness and their mode of action. This chapter also presents the history, objectives and principles of seed potato certification schemes and their role in minimising the spread of viruses within potato crops worldwide.