Botrytis cinerea is responsible of the gray mold disease on a wide range of host plants. During the infection process, it produces unspecific phytotoxins (botrydial and botcinic acid) and other secondary metabolites that play a significanT role in plant tissue colonization. Regulation of the biosynthesis of these bioactive compounds is therefore crucial for the outcome of fungus/plant interactions. Combining genetics and transcriptomic approaches, the role of different signaling cascades, transcription factors, and other regulators such as those belonging to the VELVET complex have recently been investigated. Overall, these studies suggest a strong link between the regulation of secondary metabolism and the light-dependent development in B.cinerea. Further knowledge of the complex regulatory network controlling secondary metabolism in B.cinera is crucial to understand the interaction between B.cinerea and its different host plants and may help to define new strategies to control this crop-devastating fungus.