Diseases caused by plant pathogenic bacteria have attained great concern worldwide as they are responsible for severe economic losses throughout the cultivated areas. Although studies performed in experimental conditions have provided many new insights into chemical and molecular signaling between plants and bacterial pathogens during pathogenesis, little is known about the factors that interact in natural field conditions. In particular, a wide gap exists between these two systems in terms of disease occurrence and severity. This review attempts to highlight the possible reasons that make natural field conditions different from the experimental ones, which might be useful to bridge the current gap and to facilitate the development of adequate control measures.