Altered embryo-maternal interactions affect placental development with a subsequent impact on foetal growth, pregnancy outcome and postnatal health. Our recent transcriptome analyses have revealed global perturba- tions of endometrial physiology in early pregnant cows carrying embryos produced by somatic cell nuclear transfer (SCNT). To gain new insights on molecular mechanisms taking place in the endometrium during normal and perturbed implantation, we characterized the gene expression and regulation of selected STAT/SOCS factors, a major endometrial transduction pathway for successful implantation. Expression of STAT1 and SOCS genes was analysed in the endometrium of cyclic and pregnant cows at 16 and 20 days post-oestrus (dpo). Quantitative analyses (RT-qPCR, western-blotting) showed a higher impact of the conceptus on the endometrial expression of STAT1/SOCS genes at 20 dpo of pregnancy than at 16 dpo. At 20 dpo of pregnancy compared to oestrous cycle, STAT1, SOCS1, -3, -6 mRNA levels were up-regulated (6.7-fold, p<0.001; 1.8-fold, p<0.01; 2.4-fold, p<0.05; and 3.4-fold, p<0.001 respectively) whereas SOCS2 was down-regulated (0.6-fold, p<0.05). No regulation of CISH transcript expression was observed. Interestingly, SOCS-1, -2 and -3 but not SOCS6 nor CISH appeared to be early immediate IFNT target genes in vitro and in vivo. Using immunohis- tochemistry, endometrial localisation of STAT1 and SOCS proteins showed distinct patterns of cell localization. The impact of SCNT embryos compared to in vivo produced counterparts was analysed on STAT1 and SOCS expression in endometrium collected at 20 dpo. In SCNT pregnancies, STAT1 protein level was up-regulated (1.9-fold, p<0.05).whereas SOCS3 and CISH transcript expression was down-regulated (0.2 and 0.25-fold, p<0.05).Collectively, expression of STAT1 and SOCS3 genes has appeared to be the most affected by the type of embryo and its potential of term devel- opment. Additional studies will be necessary to clarify the biological functions of STAT1 and SOCS factors in normal and perturbed endometrial physiology.