Skip to Main content Skip to Navigation
Conference papers

Un modèle animal d'étude in vivo d'une réponse immune innée à un coronavirus : la production d'interféron alpha en réponse au virus de la gastro-entérite transmissible (GET) du porc

Abstract : Interferons are a family of molecules produced in response to a viral aggression. The author focuses here on alpha interferon, describing its biological properties (antiviral, immunomodulator, antitumoral and responsible for side effects such as fever), as well as its induction and production mechanisms. He used an experimental infection model in piglets with the transmissible gastroenteritis virus (TGEV) to describe the mechanism of alpha interferon production, the exact nature of the producing cells, which are neither T lymphocytes nor B lymphocytes, but which express the class II major histocompatibility complex. Cells with the same properties are found in man’s respiratory tract and nasal mucosa. As coronaviruses are known to trigger a very strong secretion of interferon, the author suggests the following applications: monitoring interferon blood levels as a diagnostic aid in SARS, using interferon to create a vaccine, and using its possible connection with the intensity of clinical signs, and with individual sensitivity to the virus.
Document type :
Conference papers
Complete list of metadata

https://hal.inrae.fr/hal-02834151
Contributor : Migration Prodinra Connect in order to contact the contributor
Submitted on : Sunday, June 7, 2020 - 8:52:22 AM
Last modification on : Saturday, July 3, 2021 - 3:43:02 AM

Identifiers

  • HAL Id : hal-02834151, version 1
  • PRODINRA : 162200

Citation

Bernard Charley. Un modèle animal d'étude in vivo d'une réponse immune innée à un coronavirus : la production d'interféron alpha en réponse au virus de la gastro-entérite transmissible (GET) du porc. Séance de l'Académie vétérinaire de France, Jun 2003, Paris, France. ⟨hal-02834151⟩

Share

Metrics

Record views

12