More than smell. COVID-19 is associated with severe impairment of smell, taste, and chemesthesis
Valentina Parma
(1)
,
Kathrin Ohla
(2)
,
Maria G Veldhuizen
(3)
,
Masha Niv
(4)
,
Christine E. Kelly
(5)
,
Alyssa J Bakke
(6)
,
Keiland W Cooper
(7)
,
Cédric Bouysset
(8)
,
Nicola Pirastu
(9)
,
Michele Dibattista
(10)
,
Rishemjit Kaur
(11)
,
Marco Liuzza
(12)
,
Marta y Pepino
(13)
,
Veronika Schöpf
(14)
,
Veronica Pereda-Loth
(15)
,
Shannon B Olsson
(16)
,
Richard C Gerkin
(17)
,
Paloma Rohlfs Domínguez
(18)
,
Javier Albayay
(19)
,
Michael C Farruggia
(20)
,
Surabhi Bhutani
(21)
,
Alexander W Fjaeldstad
(22)
,
Ritesh Kumar
(23)
,
Anna Menini
(24)
,
Moustafa Bensafi
(25)
,
Mari Sandell
(26, 27)
,
Iordanis Konstantinidis
(28)
,
Antonella Di Pizio
(29)
,
Federica Genovese
(30)
,
Lina Öztürk
(3)
,
Thierry Thomas-Danguin
(31, 32)
,
Johannes Frasnelli
(33)
,
Sanne Boesveldt
(34)
,
Özlem Saatci
(35)
,
Luis R Saraiva
(36)
,
Cailu Lin
(30)
,
Sébastien Fiorucci
(37)
,
Jérôme Golebiowski
(37)
,
Liang-Dar Hwang
(38)
,
Hakan Ozdener
(30)
,
Maria Dolors Guardia
(39)
,
Christophe Laudamiel
(40)
,
Marina Ritchie
(7)
,
Jan Havlícek
(41)
,
Denis Pierron
(42)
,
Eugeni Roura
(38)
,
Marta Navarro
(38)
,
Alissa A Nolden
(43)
,
Juyun Lim
(44)
,
K L Whitcroft
(45)
,
Lauren R Colquitt
(30)
,
Camille Ferdenzi
(46)
,
Evelyn V Brindha
(47)
,
Aytug Altundag
(48)
,
Alberto Macchi
(49)
,
Alexia Nunez-Parra
,
Zara M Patel
(50)
,
Carl M Philpott
(51)
,
Barry Smith
(52)
,
Johan N. Lundström
(30)
,
Carla Mucignat
(19)
,
Jane Parker
(53)
,
Mirjam van den Brink
(54)
,
Michael Schmuker
(55)
,
Florian Ph S Fischmeister
(56)
,
Thomas Heinbockel
(57)
,
Vonnie D C Shields
(58)
,
Farhoud Faraji
(59)
,
Enrique Santamaria
(60)
,
William E A Fredborg
(61)
,
Gabriella Morini
(62)
,
Jonas K Olofsson
(61)
,
Maryam Jalessi
(63)
,
Noam Karni
,
Anna d'Errico
(64)
,
Rafieh Alizadeh
(63)
,
Robert Pellegrino
(65)
,
Pablo Meyer
(66)
,
Caroline Huart
(67)
,
Ben Chen
(68)
,
Graciela M Soler
(69)
,
Mohammed K Alwashahi
(70)
,
Forschungszentrum Jülich
,
Gccr Group
(71, 30, 59, 72, 73, 74, 75, 76, 77, 78, 79, 3, 80, 41, 81, 82, 83, 4, 84, 85, 86, 87, 88, 89, 90)
,
Danielle R. Reed
(30)
,
Thomas Hummel
(84)
,
Steven D. Munger
(91)
,
John E. Hayes
(92)
1
Temple University [Philadelphia]
2 FZJ - Forschungszentrum Jülich GmbH | Centre de recherche de Jülich | Jülich Research Centre
3 Mersin University
4 HUJ - The Hebrew University of Jerusalem
5 AbScent
6 Penn State - Pennsylvania State University
7 UC Irvine - University of California [Irvine]
8 UniCA - Université Côte d'Azur
9 Edin. - University of Edinburgh
10 UNIBA - Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro
11 CSIR - Central Scientific Instruments Organisation
12 UMG - Università degli Studi "Magna Graecia" di Catanzaro = University of Catanzaro
13 UIUC - University of Illinois at Urbana-Champaign [Urbana]
14 Medizinische Universität Wien = Medical University of Vienna
15 GSBMS - Groupement scientifique de Biologie et de Medecine Spatiale
16 TIFR - Tata Institute for Fundamental Research
17 ASU - Arizona State University [Tempe]
18 UEX - Universidad de Extremadura - University of Extremadura
19 Unipd - Università degli Studi di Padova = University of Padua
20 YSM - Yale School of Medicine [New Haven, Connecticut]
21 SDSU - San Diego State University
22 Aarhus University [Aarhus]
23 UH - University of Hertfordshire [Hatfield]
24 SISSA / ISAS - Scuola Internazionale Superiore di Studi Avanzati / International School for Advanced Studies
25 Neurosciences Sensorielles Comportement Cognition
26 Helsingin yliopisto = Helsingfors universitet = University of Helsinki
27 University of Turku
28 Aristotle University of Thessaloniki
29 Leibniz-Institute for Food Systems Biology at the Technical University of Munich
30 Monell Chemical Senses Center
31 CSGA - Centre des Sciences du Goût et de l'Alimentation [Dijon]
32 UBFC - Université Bourgogne Franche-Comté [COMUE]
33 UdeM - Université de Montréal
34 WUR - Wageningen University and Research [Wageningen]
35 Medical Science University
36 Sidra Medicine [Doha, Qatar]
37 ICN - Institut de Chimie de Nice
38 USQ - University of Southern Queensland
39 IRTA - Institut de Recerca i Tecnologia Agroalimentàries = Institute of Agrifood Research and Technology
40 DreamAir Llc
41 UK - Univerzita Karlova [Praha, Česká republika] = Charles University [Prague, Czech Republic]
42 AMIS - Anthropologie Moléculaire et Imagerie de Synthèse
43 UMASS - University of Massachusetts System
44 OSU - Oregon State University
45 Ear Institute, UCL
46 Lyon Neuroscience Research center
47 Karunya University
48 Biruni University
49 Assi Sette Llaghi Varese
50 Stanford School of Medicine [Stanford]
51 UEA - University of East Anglia [Norwich]
52 CDFA - California Department of Food and Agriculture
53 Unité mixte de recherche interactions plantes-microorganismes
54 Maastricht University [Maastricht]
55 Institute for Biology - Neurobiology
56 Karl-Franzens-Universität Graz
57 Howard University College of Medicine
58 Towson University
59 UC San Diego - University of California [San Diego]
60 Proteomics
61 Stockholm University
62 University of Gastronomic Sciences
63 Iran University of Medical Sciences
64 Goethe-Universität Frankfurt am Main
65 University of Tennessee
66 IBM T.J. Watson Research Center
67 ULB - Université libre de Bruxelles
68 GMU - Guangzhou Medical University
69 Buenos Aires University and GEOG (Grupo de Estudio de Olfato y Gusto)
70 SQU - Sultan Qaboos University
71 FUTA - Federal University of Technology of Akure
72 A.N. Severtsov Institute of Ecology and Evolution
73 Xjtu - Xi'an Jiaotong University
74 University of Pennsylvania
75 University of Dayton
76 CSIRO AF - CSIRO Agriculture and Food
77 Indiana University [Bloomington]
78 Northumbria University [Newcastle]
79 University of Stirling
80 METU - Middle East Technical University [Ankara]
81 Universiteit Utrecht / Utrecht University [Utrecht]
82 Instituto Universitario del Hospital Italiano [Buenos Aires, Argentina]
83 IPM - Institute for Research in Fundamental Sciences [Tehran]
84 TU Dresden - Technische Universität Dresden = Dresden University of Technology
85 Terrazas del Club Hipico
86 UMCL - University Medical Centre Ljubljana [Ljubljana, Slovenia]
87 Tata Institute of Fundamental Research [Bangalore]
88 USP - Universidade de São Paulo = University of São Paulo
89 UF - University of Florida [Gainesville]
90 University of Colorado Anschutz Medical Campus [Aurora]
91 Center for Smell and Taste
92 Department of Food Science
2 FZJ - Forschungszentrum Jülich GmbH | Centre de recherche de Jülich | Jülich Research Centre
3 Mersin University
4 HUJ - The Hebrew University of Jerusalem
5 AbScent
6 Penn State - Pennsylvania State University
7 UC Irvine - University of California [Irvine]
8 UniCA - Université Côte d'Azur
9 Edin. - University of Edinburgh
10 UNIBA - Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro
11 CSIR - Central Scientific Instruments Organisation
12 UMG - Università degli Studi "Magna Graecia" di Catanzaro = University of Catanzaro
13 UIUC - University of Illinois at Urbana-Champaign [Urbana]
14 Medizinische Universität Wien = Medical University of Vienna
15 GSBMS - Groupement scientifique de Biologie et de Medecine Spatiale
16 TIFR - Tata Institute for Fundamental Research
17 ASU - Arizona State University [Tempe]
18 UEX - Universidad de Extremadura - University of Extremadura
19 Unipd - Università degli Studi di Padova = University of Padua
20 YSM - Yale School of Medicine [New Haven, Connecticut]
21 SDSU - San Diego State University
22 Aarhus University [Aarhus]
23 UH - University of Hertfordshire [Hatfield]
24 SISSA / ISAS - Scuola Internazionale Superiore di Studi Avanzati / International School for Advanced Studies
25 Neurosciences Sensorielles Comportement Cognition
26 Helsingin yliopisto = Helsingfors universitet = University of Helsinki
27 University of Turku
28 Aristotle University of Thessaloniki
29 Leibniz-Institute for Food Systems Biology at the Technical University of Munich
30 Monell Chemical Senses Center
31 CSGA - Centre des Sciences du Goût et de l'Alimentation [Dijon]
32 UBFC - Université Bourgogne Franche-Comté [COMUE]
33 UdeM - Université de Montréal
34 WUR - Wageningen University and Research [Wageningen]
35 Medical Science University
36 Sidra Medicine [Doha, Qatar]
37 ICN - Institut de Chimie de Nice
38 USQ - University of Southern Queensland
39 IRTA - Institut de Recerca i Tecnologia Agroalimentàries = Institute of Agrifood Research and Technology
40 DreamAir Llc
41 UK - Univerzita Karlova [Praha, Česká republika] = Charles University [Prague, Czech Republic]
42 AMIS - Anthropologie Moléculaire et Imagerie de Synthèse
43 UMASS - University of Massachusetts System
44 OSU - Oregon State University
45 Ear Institute, UCL
46 Lyon Neuroscience Research center
47 Karunya University
48 Biruni University
49 Assi Sette Llaghi Varese
50 Stanford School of Medicine [Stanford]
51 UEA - University of East Anglia [Norwich]
52 CDFA - California Department of Food and Agriculture
53 Unité mixte de recherche interactions plantes-microorganismes
54 Maastricht University [Maastricht]
55 Institute for Biology - Neurobiology
56 Karl-Franzens-Universität Graz
57 Howard University College of Medicine
58 Towson University
59 UC San Diego - University of California [San Diego]
60 Proteomics
61 Stockholm University
62 University of Gastronomic Sciences
63 Iran University of Medical Sciences
64 Goethe-Universität Frankfurt am Main
65 University of Tennessee
66 IBM T.J. Watson Research Center
67 ULB - Université libre de Bruxelles
68 GMU - Guangzhou Medical University
69 Buenos Aires University and GEOG (Grupo de Estudio de Olfato y Gusto)
70 SQU - Sultan Qaboos University
71 FUTA - Federal University of Technology of Akure
72 A.N. Severtsov Institute of Ecology and Evolution
73 Xjtu - Xi'an Jiaotong University
74 University of Pennsylvania
75 University of Dayton
76 CSIRO AF - CSIRO Agriculture and Food
77 Indiana University [Bloomington]
78 Northumbria University [Newcastle]
79 University of Stirling
80 METU - Middle East Technical University [Ankara]
81 Universiteit Utrecht / Utrecht University [Utrecht]
82 Instituto Universitario del Hospital Italiano [Buenos Aires, Argentina]
83 IPM - Institute for Research in Fundamental Sciences [Tehran]
84 TU Dresden - Technische Universität Dresden = Dresden University of Technology
85 Terrazas del Club Hipico
86 UMCL - University Medical Centre Ljubljana [Ljubljana, Slovenia]
87 Tata Institute of Fundamental Research [Bangalore]
88 USP - Universidade de São Paulo = University of São Paulo
89 UF - University of Florida [Gainesville]
90 University of Colorado Anschutz Medical Campus [Aurora]
91 Center for Smell and Taste
92 Department of Food Science
Valentina Parma
- Fonction : Auteur
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- ORCID : 0000-0003-0276-7072
Kathrin Ohla
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Alyssa J Bakke
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Keiland W Cooper
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Cédric Bouysset
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Veronica Pereda-Loth
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Richard C Gerkin
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Michael C Farruggia
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Alexander W Fjaeldstad
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Moustafa Bensafi
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Thierry Thomas-Danguin
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Luis R Saraiva
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Cailu Lin
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Sébastien Fiorucci
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Jérôme Golebiowski
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Denis Pierron
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Eugeni Roura
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Camille Ferdenzi
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Alberto Macchi
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Alexia Nunez-Parra
- Fonction : Auteur
Barry Smith
- Fonction : Auteur
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Jonas K Olofsson
- Fonction : Auteur
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Noam Karni
- Fonction : Auteur
Rafieh Alizadeh
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Forschungszentrum Jülich
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Gccr Group
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Danielle R. Reed
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Thomas Hummel
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Résumé
Recent anecdotal and scientific reports have provided evidence of a link between COVID-19 and chemosensory impairments such as anosmia. However, these reports have downplayed or failed to distinguish potential effects on taste, ignored chemesthesis, and generally lacked quantitative measurements. Here, we report the development, implementation and initial results of a multi-lingual, international questionnaire to assess self-reported quantity and quality of perception in three distinct chemosensory modalities (smell, taste, and chemesthesis) before and during COVID-19. In the first 11 days after questionnaire launch, 4039 participants (2913 women, 1118 men, 8 other, ages 19-79) reported a COVID-19 diagnosis either via laboratory tests or clinical assessment. Importantly, smell, taste and chemesthetic function were each significantly reduced compared to their status before the disease. Difference scores (maximum possible change +/-100) revealed a mean reduction of smell (-79.7 +/- 28.7, mean +/- SD), taste (-69.0 +/- 32.6), and chemesthetic (-37.3 +/- 36.2) function during COVID-19. Qualitative changes in olfactory ability (parosmia and phantosmia) were relatively rare and correlated with smell loss. Importantly, perceived nasal obstruction did not account for smell loss. Furthermore, chemosensory impairments were similar between participants in the laboratory test and clinical assessment groups. These results show that COVID-19-associated chemosensory impairment is not limited to smell, but also affects taste and chemesthesis. The multimodal impact of COVID-19 and lack of perceived nasal obstruction suggest that SARS-CoV-2 infection may disrupt sensory-neural mechanisms.
| Origine | Fichiers produits par l'(les) auteur(s) |
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