Skip to Main content Skip to Navigation
Journal articles

Abundance, Diversity and Role of ICEs and IMEs in the Adaptation of Streptococcus salivarius to the Environment

Abstract : Streptococcus salivarius is a significant contributor to the human oral, pharyngeal and gut microbiomes that contribute to the maintenance of health. The high genomic diversity observed in this species is mainly caused by horizontal gene transfer. This work aimed to evaluate the contribution of integrative and conjugative elements (ICEs) and integrative and mobilizable elements (IMEs) in S. salivarius genome diversity. For this purpose, we performed an in-depth analysis of 75 genomes of S. salivarius and searched for signature genes of conjugative and mobilizable elements. This analysis led to the retrieval of 69 ICEs, 165 IMEs and many decayed elements showing their high prevalence in S. salivarius genomes. The identification of almost all ICE and IME boundaries allowed the identification of the genes in which these elements are inserted. Furthermore, the exhaustive analysis of the adaptation genes carried by these elements showed that they encode numerous functions such as resistance to stress, to antibiotics or to toxic compounds, and numerous enzymes involved in diverse cellular metabolic pathways. These data support the idea that not only ICEs but also IMEs and decayed elements play an important role in S. salivarius adaptation to the environment.
Complete list of metadata

Cited literature [76 references]  Display  Hide  Download

https://hal.inrae.fr/hal-02922962
Contributor : Julie Lao <>
Submitted on : Wednesday, August 26, 2020 - 4:36:46 PM
Last modification on : Thursday, May 6, 2021 - 10:50:58 AM

File

genes-11-00999.pdf
Files produced by the author(s)

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Citation

Julie Lao, Gérard Guédon, Thomas Lacroix, Florence Charron-Bourgoin, Virginie Libante, et al.. Abundance, Diversity and Role of ICEs and IMEs in the Adaptation of Streptococcus salivarius to the Environment. Genes, MDPI, 2020, ⟨10.3390/genes11090999⟩. ⟨hal-02922962⟩

Share

Metrics

Record views

117

Files downloads

79