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Lighting chaperone-mediated autophagy (CMA) evolution with an ancient LAMP: the existence of a functional CMA activity in fish

Abstract : Chaperone-mediated autophagy (CMA), as one of the main pathways of lysosomal catabolism, plays essential roles for the maintenance of cellular homeostasis. To date, the absence of any identifiable LAMP2A – the necessary and limiting protein required for CMA – in non-tetrapod lineages, led to the paradigm that this cellular process was restricted to mammals and birds. The recent findings of Lescat et al., demonstrating the existence of a CMA activity in fish, now reshuffle the cards regarding how the entire evolution of CMA function should be considered and appreciated across metazoans. Hence, beyond challenging the current tetrapod-centered accepted view, the work of Lescat et al. tackles the possibility – or the compelling need – of using complementary and powerful genetic models, such as zebrafish or medaka, for studying this fundamental function from an evolutionary perspective
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https://hal.inrae.fr/hal-02924565
Contributor : Pascale Avril <>
Submitted on : Friday, August 28, 2020 - 10:58:08 AM
Last modification on : Wednesday, May 26, 2021 - 5:28:02 PM

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Amaury Herpin, Laury Lescat, Julien Bobe, Andreas Jenny, Iban Seiliez. Lighting chaperone-mediated autophagy (CMA) evolution with an ancient LAMP: the existence of a functional CMA activity in fish. Autophagy, Taylor & Francis, 2020, 16 (10), pp.1918-1920. ⟨10.1080/15548627.2020.1797344⟩. ⟨hal-02924565⟩

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