Parsimonious discretization for characterizing multi‐exponential decay in magnetic resonance - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Accéder directement au contenu
Article Dans Une Revue NMR in Biomedicine Année : 2020

Parsimonious discretization for characterizing multi‐exponential decay in magnetic resonance

J.-M. Bonny
Amidou Traore
Mustapha Bouhrara
  • Fonction : Auteur
  • PersonId : 767697
  • IdRef : 164941029
Guilhem Pagès

Résumé

We address the problem of analyzing noise-corrupted magnetic resonance transverse decay signals as a superposition of underlying independently decaying monoexponentials of positive amplitude. First, we indicate the manner in which this is an ill-conditioned inverse problem, rendering the analysis unstable with respect to noise. Second, we define an approach to this analysis, stabilized solely by the nonnegativity constraint without regularization. This is made possible by appropriate discretization, which is coarser than that often used in practice. Thirdly, we indicate further stabilization by inspecting the plateaus of cumulative distributions. We demonstrate our approach through analysis of simulated myelin water fraction measurements, and compare the accuracy with more conventional approaches. Finally, we apply our method to brain imaging data obtained from a human subject, showing that our approach leads to maps of the myelin water fraction which are much more stable with respect to increasing noise than those obtained with conventional approaches.

Dates et versions

hal-02926295 , version 1 (31-08-2020)

Licence

Paternité

Identifiants

Citer

J.-M. Bonny, Amidou Traore, Mustapha Bouhrara, Richard Spencer, Guilhem Pagès. Parsimonious discretization for characterizing multi‐exponential decay in magnetic resonance. NMR in Biomedicine, 2020, 33 (12), ⟨10.1002/nbm.4366⟩. ⟨hal-02926295⟩

Collections

INRAE
21 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More