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Characterization of internal ribosome entry sites according to secondary structure analysis to classify border disease virus strains

Abstract : Applying palindromic nucleotide substitutions (PNS) method, variable loci of the internal ribosome entry site (IRES) secondary structure in the 5' untranslated region (UTR) of Border disease virus sequences were analysed allowing their allocation into ten IRES classes within the species. Sequence characteristics of Turkish and Chinese strains were highly divergent from other genogroups, indicating geographic segregation and micro-evolutive steps within the species. Observed heterogeneity in the BDV species has to be considered for potential implications on diagnostic tests, control and preventive measures.
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https://hal.inrae.fr/hal-02937517
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Submitted on : Monday, September 14, 2020 - 10:00:35 AM
Last modification on : Wednesday, March 2, 2022 - 8:58:01 AM

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Massimo Giangaspero, Falko Steinbach, Rebecca Strong, Nicola Decaro, Canio Buonavoglia, et al.. Characterization of internal ribosome entry sites according to secondary structure analysis to classify border disease virus strains. Journal of Virological Methods, Elsevier, 2020, 275, pp.113704. ⟨10.1016/j.jviromet.2019.113704⟩. ⟨hal-02937517⟩

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