The LifeCycle Project-EU Child Cohort Network: a federated analysis infrastructure and harmonized data of more than 250,000 children and parents - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement
Journal Articles European Journal of Epidemiology Year : 2020

The LifeCycle Project-EU Child Cohort Network: a federated analysis infrastructure and harmonized data of more than 250,000 children and parents

14 · Rachel Foong 15,16 · Veit Grote 17 · Sido Haakma 18 · Mark Hanson 19,20 · Jennifer R. Harris 21,22 · Barbara Heude 4 · Rae-Chi Huang 15 · Hazel Inskip 20

1 Erasmus MC - Erasmus University Medical Center [Rotterdam]
2 CIBERESP - Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública = Consortium for Biomedical Research of Epidemiology and Public Health
3 CRESS (U1153 / UMR_A 1125) - Centre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques
4 ISGlobal - Instituto de Salud Global - Institute For Global Health [Barcelona]
5 UPF - Universitat Pompeu Fabra [Barcelona]
6 IMIM-Hospital del Mar
7 IISPV - Institut d'Investigació Sanitària Pere Virgili [Tarragona]
8 BioDonostia Health Research Institute = Instituto de Investigación Sanitaria Biodonostia
9 UPV / EHU - Universidad del País Vasco [Espainia] / Euskal Herriko Unibertsitatea [España] = University of the Basque Country [Spain] = Université du pays basque [Espagne]
10 FISABIO - Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana [Espagne]
11 UV - Universitat de València
12 Conselleria de Sanitat
13 UNITO - Università degli studi di Torino = University of Turin
14 University of Southampton
15 University of Bristol [Bristol]
16 ITU - IT University of Copenhagen
17 BIHR - Bradford Institute for Health Research, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UK
18 University of Manchester [Manchester]
19 University of Groningen [Groningen]
20 UOC - University of Crete [Heraklion]
21 USC - University of Southern California
22 NIPH - Norwegian Institute of Public Health [Oslo]
23 ELFE - Etude longitudinale française depuis l'enfance (UMS : Ined-Inserm-EFS)
24 IAB - Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble)
25 iPLESP - Institut Pierre Louis d'Epidémiologie et de Santé Publique
Veit Grote
Lifecycle Project Group
  • Function : Author

Abstract

Early life is an important window of opportunity to improve health across the full lifecycle. An accumulating body of evidence suggests that exposure to adverse stressors during early life leads to developmental adaptations, which subsequently affect disease risk in later life. Also, geographical, socio-economic, and ethnic differences are related to health inequalities from early life onwards. To address these important public health challenges, many European pregnancy and childhood cohorts have been established over the last 30 years. The enormous wealth of data of these cohorts has led to important new biological insights and important impact for health from early life onwards. The impact of these cohorts and their data could be further increased by combining data from different cohorts. Combining data will lead to the possibility of identifying smaller effect estimates, and the opportunity to better identify risk groups and risk factors leading to disease across the lifecycle across countries. Also, it enables research on better causal understanding and modelling of life course health trajectories. The EU Child Cohort Network, established by the Horizon2020-funded LifeCycle Project, brings together nineteen pregnancy and childhood cohorts, together including more than 250,000 children and their parents. A large set of variables has been harmonised and standardized across these cohorts. The harmonized data are kept within each institution and can be accessed by external researchers through a shared federated data analysis platform using the R-based platform DataSHIELD, which takes relevant national and international data regulations into account. The EU Child Cohort Network has an open character. All protocols for data harmonization and setting up the data analysis platform are available online. The EU Child Cohort Network creates great opportunities for researchers to use data from different cohorts, during and beyond the LifeCycle Project duration. It also provides a novel model for collaborative research in large research infrastructures with individual-level data. The LifeCycle Project will translate results from research using the EU Child Cohort Network into recommendations for targeted prevention strategies to improve health trajectories for current and future generations by optimizing their earliest phases of life.
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hal-02938634 , version 1 (04-09-2024)

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Vincent W V Jaddoe, Janine F Felix, Anne-Marie Nybo Andersen, Marie-Aline Charles, Leda Chatzi, et al.. The LifeCycle Project-EU Child Cohort Network: a federated analysis infrastructure and harmonized data of more than 250,000 children and parents. European Journal of Epidemiology, 2020, 35 (7), pp.709-724. ⟨10.1007/s10654-020-00662-z⟩. ⟨hal-02938634⟩
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