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A Capsule-Based Model for Immature Hard Tick Stages Infestation on Laboratory Mice

Abstract : Ticks are obligatory blood feeding parasites at all stages of development (except eggs) and are recognized as vectors of various pathogens. The use of mouse models in tick research is critical for understanding their biology and tick-host-pathogen interactions. Here we demonstrate a non-laborious technique for the feeding of immature stages of hard ticks on laboratory mice. The benefit of the method is its simplicity, short duration, and the ability to monitor or collect ticks at different time points of an experiment. In addition, the technique allows attachment of two individual capsules on the same mouse, which is beneficial for a variety of experiments where two different groups of ticks are required to feed on the same animal. The non-irritating and flexible capsule is made from easily accessible materials and minimizes the discomfort of the experimental animals. Furthermore, euthanasia is not necessary, mice recover completely after the experiment and are available for re-use.
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Contributor : Alejandro Cabezas-Cruz <>
Submitted on : Monday, September 28, 2020 - 11:28:32 PM
Last modification on : Wednesday, June 2, 2021 - 4:02:07 PM
Long-term archiving on: : Tuesday, December 29, 2020 - 7:23:09 PM


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Lourdes Mateos Hernandez, Sabine Rakotobe, Baptiste Defaye, Alejandro Cabezas Cruz, Ladislav Simo. A Capsule-Based Model for Immature Hard Tick Stages Infestation on Laboratory Mice. Journal of visualized experiments : JoVE, JoVE, 2020, ⟨10.3791/61430⟩. ⟨hal-02951801⟩



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