Skip to Main content Skip to Navigation
Journal articles

Clinical research assessment by flow cytometry of biomarkers for infectious stratification in an Emergency Department

Abstract : Management of patients with infections within the Emergency Department (ED) is challenging for practitioners, as the identification of infectious causes remains difficult with current techniques. A new combination of two biomarkers was tested with a new rapid flow cytometry technique. Materials & methods: Subjects from the ED were tested for their CD64 on neutrophils (nCD64) and CD169 on monocytes (mCD169) levels and results were compared to their clinical records. Results: Among 139 patients, 29% had confirmed bacterial infections and 5% viral infections. nCD64 and mCD169 respectively showed 88 and 86% sensitivity and 90 and 100% specificity for identifying subjects in bacterial or viral conditions. Conclusion: This point-of-care technique could allow better management of patients in the ED.
Document type :
Journal articles
Complete list of metadata

https://hal.inrae.fr/hal-02972338
Contributor : Nelly Lucas <>
Submitted on : Tuesday, October 20, 2020 - 12:43:53 PM
Last modification on : Tuesday, March 23, 2021 - 3:30:48 AM

Identifiers

Collections

Citation

Penelope Bourgoin, Thomas Soliveres, Dalia Ahriz, Isabelle Arnoux, Christian Meisel, et al.. Clinical research assessment by flow cytometry of biomarkers for infectious stratification in an Emergency Department. Biomarkers in Medicine, Future Medicine, 2019, 13 (16), pp.1373-1386. ⟨10.2217/bmm-2019-0214⟩. ⟨hal-02972338⟩

Share

Metrics

Record views

31