Skip to Main content Skip to Navigation
Journal articles

Evidence for hormonal control of heart regenerative capacity during endothermy acquisition

Abstract : Tissue regenerative potential displays striking divergence across phylogeny and ontogeny, but the underlying mechanisms remain enigmatic. Loss of mammalian cardiac regenerative potential correlates with cardiomyocyte cell-cycle arrest and polyploidization as well as the development of postnatal endothermy. We reveal that diploid cardiomyocyte abundance across 41 species conforms to Kleiber's law-the 3/4 -power law scaling of metabolism with bodyweight-and inversely correlates with standard metabolic rate, body temperature, and serum thyroxine level. Inactivation of thyroid hormone signaling reduces mouse cardiomyocyte polyploidization, delays cell-cycle exit, and retains cardiac regenerative potential in adults. Conversely, exogenous thyroid hormones inhibit zebrafish heart regeneration. Thus, our findings suggest that loss of heart regenerative capacity in adult mammals is triggered by increasing thyroid hormones and may be a trade-off for the acquisition of endothermy.
Document type :
Journal articles
Complete list of metadata
Contributor : Christopher Lallemant <>
Submitted on : Friday, October 30, 2020 - 11:11:45 AM
Last modification on : Friday, May 21, 2021 - 6:12:02 PM

Links full text




Kentaro Hirose, Alexander Payumo, Stephen Cutie, Alison Hoang, Hao Zhang, et al.. Evidence for hormonal control of heart regenerative capacity during endothermy acquisition. Science, American Association for the Advancement of Science, 2019, pp.eaar2038. ⟨10.1126/science.aar2038⟩. ⟨hal-02983719⟩



Record views