Evidence for hormonal control of heart regenerative capacity during endothermy acquisition - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Access content directly
Journal Articles Science Year : 2019

Evidence for hormonal control of heart regenerative capacity during endothermy acquisition

Hao Zhang
  • Function : Author
Romain Guyot
Megan Smith

Abstract

Tissue regenerative potential displays striking divergence across phylogeny and ontogeny, but the underlying mechanisms remain enigmatic. Loss of mammalian cardiac regenerative potential correlates with cardiomyocyte cell-cycle arrest and polyploidization as well as the development of postnatal endothermy. We reveal that diploid cardiomyocyte abundance across 41 species conforms to Kleiber's law-the 3/4 -power law scaling of metabolism with bodyweight-and inversely correlates with standard metabolic rate, body temperature, and serum thyroxine level. Inactivation of thyroid hormone signaling reduces mouse cardiomyocyte polyploidization, delays cell-cycle exit, and retains cardiac regenerative potential in adults. Conversely, exogenous thyroid hormones inhibit zebrafish heart regeneration. Thus, our findings suggest that loss of heart regenerative capacity in adult mammals is triggered by increasing thyroid hormones and may be a trade-off for the acquisition of endothermy.

Dates and versions

hal-02983719 , version 1 (30-10-2020)

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Kentaro Hirose, Alexander Payumo, Stephen Cutie, Alison Hoang, Hao Zhang, et al.. Evidence for hormonal control of heart regenerative capacity during endothermy acquisition. Science, 2019, pp.eaar2038. ⟨10.1126/science.aar2038⟩. ⟨hal-02983719⟩
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