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International consensus conference on stool banking for faecal microbiota transplantation in clinical practice

Giovanni Cammarota 1, * Gianluca Ianiro 1 Colleen Kelly 2 Benjamin Mullish 3, 4 Jessica Allegretti 5 Zain Kassam 6, 7 Lorenza Putignani 8 Monika Fischer 9 Josbert Keller 10, 11 Samuel Paul Costello 12 Harry Sokol 13, 14, 15 Patrizia Kump 16 Reetta Satokari 17 Stacy Kahn 18 Dina Kao 19 Perttu Arkkila 20 Ed Kuijper 21 Maria Vehreschild 22 Cristina Pintus 23 Loris Lopetuso 24 Luca Masucci 25 Franco Scaldaferri 24 E Terveer 11, 21 Max Nieuwdorp 26 Antonio López-Sanromán 27 Juozas Kupcinskas 28 Ailsa Hart 29 Herbert Tilg 30 Antonio Gasbarrini 31
Abstract : Although faecal microbiota transplantation (FMT) has a well-established role in the treatment of recurrent Clostridioides difficile infection (CDI), its widespread dissemination is limited by several obstacles, including lack of dedicated centres, difficulties with donor recruitment and complexities related to regulation and safety monitoring. Given the considerable burden of CDI on global healthcare systems, FMT should be widely available to most centres. Stool banks may guarantee reliable, timely and equitable access to FMT for patients and a traceable workflow that ensures safety and quality of procedures. In this consensus project, FMT experts from Europe, North America and Australia gathered and released statements on the following issues related to the stool banking: general principles, objectives and organisation of the stool bank; selection and screening of donors; collection, preparation and storage of faeces; services and clients; registries, monitoring of outcomes and ethical issues; and the evolving role of FMT in clinical practice, Consensus on each statement was achieved through a Delphi process and then in a plenary face-to-face meeting. For each key issue, the best available evidence was assessed, with the aim of providing guidance for the development of stool banks in order to promote accessibility to FMT in clinical practice.
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Submitted on : Friday, October 30, 2020 - 12:01:31 PM
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Giovanni Cammarota, Gianluca Ianiro, Colleen Kelly, Benjamin Mullish, Jessica Allegretti, et al.. International consensus conference on stool banking for faecal microbiota transplantation in clinical practice. Gut, BMJ Publishing Group, 2019, 68 (12), pp.2111-2121. ⟨10.1136/gutjnl-2019-319548⟩. ⟨hal-02983798⟩



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