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Journal Articles eLife Year : 2021

The rise and fall of the ancient northern pike master sex-determining gene

Eric Rondeau
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  • PersonId : 835505
Laurent Journot
Hugues Parrinello
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Manfred Schartl
John Postlethwait

Abstract

The understanding of the evolution of variable sex determination mechanisms across taxa requires comparative studies among closely related species. Following the fate of a known master sex-determining gene, we traced the evolution of sex determination in an entire teleost order (Esociformes). We discovered that the northern pike (Esox lucius) master sex-determining gene originated from a 65 to 90 million-year-old gene duplication event and that it remained sex linked on undifferentiated sex chromosomes for at least 56 million years in multiple species. We identified several independent species- or population-specific sex determination transitions, including a recent loss of a Y chromosome. These findings highlight the diversity of evolutionary fates of master sex-determining genes and the importance of population demographic history in sex determination studies. We hypothesize that occasional sex reversals and genetic bottlenecks provide a non-adaptive explanation for sex determination transitions.
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hal-03139073 , version 1 (15-03-2021)
hal-03139073 , version 2 (08-06-2021)

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Qiaowei Pan, Romain Feron, Elodie Jouanno, Hugo Darras, Amaury Herpin, et al.. The rise and fall of the ancient northern pike master sex-determining gene. eLife, 2021, 10, pp.e62858. ⟨10.7554/eLife.62858⟩. ⟨hal-03139073v2⟩
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