Sperm interactions with the female reproductive tract: A key for successful fertilization in mammals - Archive ouverte HAL Access content directly
Journal Articles (Review Article) Molecular and Cellular Endocrinology Year : 2020

Sperm interactions with the female reproductive tract: A key for successful fertilization in mammals

(1) , (1) , (1) , (1) , (1) , (1)
1

Abstract

Sperm migration through the female genital tract is not a quiet journey. Uterine contractions quickly operate a drastic selection, leading to a very restrictive number of sperm reaching the top of uterine horns and finally, provided the presence of key molecules on sperm, the oviduct, where fertilization takes place. During hours and sometimes days before fertilization, subpopulations of spermatozoa interact with dynamic and region-specific maternal components, including soluble proteins, extracellular vesicles and epithelial cells lining the lumen of the female tract. Interactions with uterine and oviductal cells play important roles for sperm survival as they modulate the maternal immune response and allow a transient storage before ovulation. The body of work reported here highlights the importance of sperm interactions with proteins originated from both the uterine and oviductal fluids, as well as hormonal signals around the time of ovulation for sperm acquisition of fertilizing competence.
Fichier principal
Vignette du fichier
S0303720720302562.pdf (942.55 Ko) Télécharger le fichier
Origin : Files produced by the author(s)

Dates and versions

hal-03150429 , version 1 (22-08-2022)

Licence

Attribution - NonCommercial - CC BY 4.0

Identifiers

Cite

Coline Mahé, Karine Reynaud, Guillaume Tsikis, Pascal Mermillod, Xavier Druart, et al.. Sperm interactions with the female reproductive tract: A key for successful fertilization in mammals. Molecular and Cellular Endocrinology, 2020, 516, pp.1-14. ⟨10.1016/j.mce.2020.110956⟩. ⟨hal-03150429⟩
25 View
22 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More